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Keywords

Congenital heart disease, Echocardiography

Abstract

Introduction: Congenital heart disease (CHD) is a leading cause of pediatric mortality globally, including in Thailand. Understanding CHD types and severity is crucial for epidemiology and patient care. Objective: This study aimed to examine demographic data, types, and severity of CHD in patients at Thammasat University Hospital from 2001 to 2020, and to compare CHD types between 2001–2010 and 2011–2020. Methods: A retrospective review collected data from pediatric patients (aged 15 years or younger) from 2001 to 2020, based on echocardiography and medical records. Demographic information, diagnosis, classification, and CHD severity were analyzed using counts and percentages. Comparisons of severity among different types of CHD, and comparisons of CHD types between the first and latter 10-year periods, were analyzed statistically. Results: A total of 2,868 patients were included. Cyanotic CHD was diagnosed in 490 patients (18.24%) and acyanotic CHD in 2,196 patients (81.76%). Among cyanotic cases, biventricular CHD comprised 65.71% and functionally univentricular CHD 34.29%. The most common acyanotic type was left-to-right shunt lesions (75.50%). CHD severity was classified as mild (38.64%), moderate (51.53%), and severe (9.83%). Severity differed significantly between CHD types (cyanotic vs. acyanotic, p < 0.001) and within cyanotic CHD (biventricular vs. functionally univentricular, p < 0.001). No statistically significant differences in CHD type distribution were observed between 2001–2010 and 2011–2020, regardless of cyanotic vs. acyanotic CHD (p = 0.522), biventricular vs. functionally univentricular CHD (p = 0.463), or acyanotic CHD classified by pathophysiology (p = 0.630).

References

1. Mitchell SC, Korones SB, Berendes HW. Congenital heart disease in 56,109 births. Incidence and natural history. Circulation. 1971;43(3):323–332.

2. Azhar AS, AlShammasi ZH, Higgi RE. The impact of congenital heart diseases on the quality of life of patients and their families in Saudi Arabia. Biological, psychological, and social dimensions. Saudi Med J. 2016;37(4):392–402.

3. Chong LSH, Fitzgerald DA, Craig JC, et al. Children’s experiences of congenital heart disease: A systematic review of qualitative studies. Eur J Pediatr. 2018;177(3):319–336.

4. GBD 2017 congenital heart disease collaborators. Global, regional, and national burden of congenital heart disease, 1990- 2017: A systematic analysis for the global burden of disease study 2017. Lancet Child Adolesc Health. 2020;4(3):185–200.

5. Liu Y, Chen S, Zühlke L, et al. Global birth prevalence of congenital heart defects 1970-2017: Updated systematic review and meta-analysis of 260 studies. Int J Epidemiol. 2019;48(2):455–463.

6. Ho man JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39(12):1890–1900.

7. Zhao QM, Ma XJ, Jia B, Huang GY. Prevalence of congenital heart disease at live birth: An accurate assessment by echocardiographic screening. Acta Paediatr. 2013;102(4):397–402.

8. Saxena A, Mehta A, Sharma M, et al. Birth prevalence of congenital heart disease: A cross-sectional observational study from North India. Ann Pediatr Cardiol. 2016;9(3):205–209.

9. Krishna MR, Kumar RK. Diagnosis and management of critical congenital heart diseases in the newborn. Indian J Pediatr. 2020;87(5):365–371.

10. Wren C, Richmond S, Donaldson L. Temporal variability in birth prevalence of cardiovascular malformations. Heart. 2000;83(4):414–419.

11. Hwang IC, Sisavanh M, Billamay S, et al. Congenital heart disease at laos children’s hospital: Two year experience. Pediatr Int. 2017;59(3):271–279.

12. Ishikawa T, Iwashima S, Ohishi A, Nakagawa Y, Ohzeki T. Prevalence of congenital heart disease assessed by echocardiography in 2067 consecutive newborns. Acta Paediatr. 2011;100(8):e55–e60.

13. EUROCAT. EUROCAT guide 1.4. Instructions for the registration of congenital anomalies. Published 2019. Accessed July 22, 2021. https://eu-rdplatform.jrc.ec.europa.eu/ eurocat/data-collection/guidelines-for-data-registration.

14. Majeed-Saidan MA, Atiyah M, Ammari AN, et al. Patterns, prevalence, risk factors, and survival of newborns with congenital heart defects in a Saudi population: a three-year, cohort case-control study. J Congenit Heart Dis. 2019. https: //doi.org/10.1186/s40949-019-0023-8.

15. Sayasathid J, Tantiwongkosri K, Somboonna N. Unrecognized congenital heart disease among Thai children. J Med Assoc Thai. 2009;92(3):356–359.

16. Cholkraisuwat E, Buddharaksa Y, Sayasathid J. Congenital heart disease in elementary school children in rural Thailand: The role of the trained noncardiologist. Asian Biomed. 2013;7(2):287–291. doi: 10.5372/1905-7415.0702.178.

17. Ratanasit N, Karaketklang K, Jakrapanichakul D, et al. Prevalence and echocardiographic characteristics of common congenital heart disease in adult patients at Siriraj Hospital: 10-year study. J Med Assoc Thai. 2015;98(1):7–13.

18. Hwang I, Sisavanh M, Billamay S, et al. Congenital heart disease at Laos Children’s Hospital: Two year experience. Pediatr Int. 2017;59(3):271–279.

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