CAR-T Cell Therapy Milestones in Treating Hematologic Malignancies

Authors

Dusit Jit-ueakul, Division of Hematology, Department of Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Piyanuch Kongtim, Hematopoietic Stem Cell Transplant and Cellular Therapy Program, Division of Hematology and Oncology, Department of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USAFollow

Abstract

Chimeric Antigen Receptor T (CAR-T) cell therapy has emerged as a revolutionary treatment modality for hematologic malignancies, including acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL), and chronic lymphocytic leukemia (CLL). This innovative approach involves the genetic engineering of a patient's own T lymphocytes to express chimeric antigen receptors (CARs), which enables these cells to specifically recognize and eliminate malignant cells expressing target antigens. Clinical trials have demonstrated remarkable efficacy, with significant rates of complete remission and durable responses observed in patients who have relapsed or are refractory to conventional therapies. As advancements in CAR technology continue, there is potential for expanding its application to other hematologic and solid tumors, offering hope for improved outcomes in cancer therapies. This article highlights the transformative impact of CAR-T cell therapy in hematologic malignancies and emphasizes the need for further investigation to enhance its safety and effectiveness.

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Recommended Citation

Jit-ueakul, Dusit and Kongtim, Piyanuch. 2025 CAR-T Cell Therapy Milestones in Treating Hematologic Malignancies. Asian Medical Journal and Alternative Medicine. 25, 3 (Dec. 2025 ), 4-10.
Available at: https://doi.org/10.70933/2773-9465.1263

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