Disseminated Nocardiosis with Intracranial Mycotic Aneurysm in A Patient with Autoimmune Hepatitis: A Case Report and Review of The Literature

Authors

Chaiwat Pongkaew, Division of Infectious Diseases, Department of Internal Medicine, Thammasat University, Pathum Thani Province, Thailand
Anucha Apisarnthanarak, Division of Infectious Diseases, Department of Internal Medicine, Thammasat University, Pathum Thani Province, Thailand
Thana Khawcharoenporn, Division of Infectious Diseases, Department of Internal Medicine, Thammasat University, Pathum Thani Province, Thailand
Nuntra Suwantarat, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand
Sasinuch Rutjanawech
Pansachee Damronglert, Division of Infectious Diseases, Department of Internal Medicine, Thammasat University, Pathum Thani, Thailand
Suttichai Visuttichaikit, Division of Infectious Diseases, Department of Internal Medicine, Thammasat University, Pathum Thani, Thailand

Abstract

We are reporting a case of disseminated Nocardia otitidiscaviarum infection, manifesting as a ruptured intracranial aneurysm in an immunocompromised patient. The patient succumbed despite treatment with trimethoprim-sulfamethoxazole, amikacin, and levofloxacin along with surgical repairment. Nocardiosis should be one of the differential diagnoses for intracranial mycotic aneurysm among immunocompromised individuals.

Running title: Nocardia intracranial aneurysm

References

Kageyama A, Yazawa K, Ishikawa J, Hotta K, Nishimura K, Mikami Y. Nocardial infections in Japan from 1992 to 2001, including the first report of infection by Nocardia transvalensis. Eur J Epidemiol. 2004;19:383-389.

Ishihara M, Takada D, Sugimoto K, et al. Primary brain abscess caused by Nocardia otitidiscaviarum. Intern Med. 2014;53(17):2007-12.

Corti ME, Villafañe-Fioti MF. Nocardiosis: a review. Int J Infect Dis. 2003;7:243-50.

Alawieh A, Chaudry M, Turner RD, Turk A0, Spiotta AM. Infectious intracranial aneurysms: a systematic review of epidemiology, management, and outcomes. J NeuroIntervent Surg. 2018;0:1-10.

Parengal J, Alebbi SM, Hamed MMM, Alqatami HM. Disseminated life threatening Nocardia otitidiscaviarum infection in a young female with newly diagnosed systemic lupus erythematosus, case report and review of literature. IDCases. 2021;26:e01265.

Farran Y, Antony S. Nocardia abscessusrelated intracranial aneurysm of the internal carotid artery with associated brain abscess: a case report and review of the literature. J Infect Public Health. 2016;9(3):358-61.

Chansirikarnjana S, Apisarnthanarak A, Suwantarat N, et al. Nocardia intracranial mycotic aneurysm associated with proteasome inhibitor. IDCases. 2019;8:e00601.

Hadley MN, Robert MD, Spetzler F, Martin NA, Johnson PC. Middle cerebral artery aneurysm due to Nocardia asteroides: case report of aneurysm excision and extracranial-intracranial bypass. Neurosurgery. 1988;22(5):923-8.

Duangprasert G, Kebboonkird D, Ratanavinitkul W, Tantongtip D. A rare case of ruptured anterior cerebral artery infected aneurysm with angioinvasion secondary to disseminated Nocardia otitidiscaviarum: A case report and literature review. Surgical Neurology International. 2022;13:417.

Betrán A, Villuendas MC, Rezusta A, et al. Cavitary pneumonia caused by Nocardia otitidiscaviarum. Braz J Microbiol. 2010;41:329-32.

Recommended Citation

Pongkaew, Chaiwat; Apisarnthanarak, Anucha; Khawcharoenporn, Thana; Suwantarat, Nuntra; Rutjanawech, Sasinuch; Damronglert, Pansachee; and Visuttichaikit, Suttichai. 2024 Disseminated Nocardiosis with Intracranial Mycotic Aneurysm in A Patient with Autoimmune Hepatitis: A Case Report and Review of The Literature. Asian Medical Journal and Alternative Medicine. 24, 1 (Dec. 2024 ), 77-82.
Available at: https://doi.org/10.70933/2773-9465.1053

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.