Quinolone-induced Torsades De Pointes: A life-threatening complication of conventional medication
Abstract
The use of antibiotic drugs, particularly the quinolone group, can cause acquired QT prolongation and blockage of the potassium channel (Ik). We report a case of torsade de pointes (TdP) triggered by the use of ciprofloxacin to treat arteriovenous fistulas infection.
References
Roden DM. Drug-induced prolongation of the QT interval. New England Journal of Medicine. 2004;350(10):1013-1022. doi:10.1056/nejmra032426
Briasoulis A, Agarwal V, Pierce WJ. QT prolongation and torsade de pointes induced by fluoroquinolones: infrequent side effects from commonly used medications. Cardiology. 2011;120(2):103-110. doi:10.1159/000334441
Viskin S. Long QT syndromes and torsade de pointes. Lancet. 1999;354(9190):1625-1633. doi:10.1016/S0140-6736(99)02107-8.
Mantri N, Lu M, Zaroff JG, et al. Torsade de Pointes: A nested case–control study in an integrated healthcare delivery system. Annals of Noninvasive Electrocardiology. 2021;27(1). doi:10.1111/anec.12888.
Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circulation Research. 1994;74(6):1097-1113. doi:10.1161/01.res.74.6.1097.
Roden DM. Predicting drug-induced qt prolongation and torsades de pointes. The Journal of Physiology. 2016;594(9):2459-2468. doi:10.1113/jp270526.
Peter J. Schwartz and Raymond L. Woosley. Predicting the unpredictable: Drug-induced qt ... - JACC journals. Journal of the American College of Cardiology . 2016. Accessed May 13, 2023. https://www.jacc.org/doi/abs/10.1016/j.jacc.2015.12.063.
Ismail Y, Ismail AA, Ismail AAA. The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for “normal” results. cclm. 2010;48(3):323-327. doi:10.1515/cclm.2010.077.
Inoue H, Matsuo H, Mashima S, Murao S. Effects of atrial pacing, isoprenaline and lignocaine on experimental polymorphic ventricular tachycardia. Cardiovasc Res. 1984;18(9):538-547. doi:10.1093/cvr/18.9.538.
Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022;43(40):3997-4126. doi:10.1093/eurheartj/ehac262.
Recommended Citation
Sojikul, Lanlalin; Chongtanapipat, Kunchanit; and Chintanavilas, Kumpul.
2023
Quinolone-induced Torsades De Pointes: A life-threatening complication of conventional medication.
Asian Medical Journal and Alternative Medicine. 23,
4 (Sep. 2025 ), S59-S64.
Available at: https://doi.org/10.70933/2773-9465.1084