Keywords
Interlaboratory comparison, Intra-class correlation coefficients, Urine, Trans, trans-muconic acid, Benzene exposure biomarker, Rayong province
Abstract
Introduction: The objective of this study was to assess reliability of urinary trans, trans-muconic acid (t,t-MA) analysis by high performance liquid chromatography (HPLC) technique among three laboratories in Rayong province.
Method: We conducted the interlaboratory comparison among three laboratories for t,t-MA testing via two steps. Step one was the preparation phase to settle the agreement and protocol. Step two was the comparison: step 2.1 the comparative HPLC-analysis of blank and spiked urines and step 2.2 the comparative HPLC-analysis of 30 urine samples obtained from subjects. Subjects were gas station workers in Rayong province.
Result: The result obtained from step 2.1 showed the good percentage of recovery and comparable results. Non significant differences between each pair of the 3 laboratories and high intra-class correlation coefficients in step 2.2 implied good reliability of 3 laboratories.
Discussion and Conclusion: This interlaboratory comparison could be considered an initiative for external quality assurance of this
laboratory testing
Recommended Citation
Intawong, Chanthip; Khunkitti, Rojana; Sripaung, Nalinee; Yapun, Chularat; Buachoom, Prathoomporn; Tupwongse, Vitchayut; and Sithisarankul, Pornchai.
2015
Interlaboratory comparison for urinary trans, trans-muconic acid testing in Rayong province.
Asian Medical Journal and Alternative Medicine. 15,
3 (Jul. 2015 ), 523-529.
Available at: https://doi.org/10.70933/2773-9465.2097
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This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
