Keywords
ABC transporter protein, Cancer drug resistance, P-glycoprotein, Breast cancer resistance protein, Multidrug resistance-associated protein 1
Abstract
Drug resistance imposes a major constraint on the successful treatment of cancer. One of the most significant factors in cancer drug resistance is efflux transporter activity. ABC (ATP-binding cassette) transporters are widely acknowledged as a class of efflux transporters, which actively efflux anticancer agents out of cells by using energy from ATP and play a crucial role on cancer drug resistance. Overexpression of P-glycoprotein (P-gp; ABCB1), breast cancer resistance protein (BCRP; ABCG2) and multidrug resistance-associated protein 1 (MRP1; ABCC1) has been reported in a variety of solid tumours and haematological malignancies and transport a variety of anticancer agents. Here, this article reviews an understanding on ABC transporter proteins in terms of structure, efflux substrate specificity, a role in physiological aspects, potential strategies and modulators to overcome ABC transporters.
Recommended Citation
Rungsardthong, Kanin.
2014
ABC transporter protein and cancer drug resistance.
Asian Medical Journal and Alternative Medicine. 14,
3 (Jul. 2014), 431-442.
Available at: https://doi.org/10.70933/2773-9465.1610
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
